Adaptation Strategies In Response Research Articles

Typology analysis and adaptive capacity of commercial gardening farmers to climate change in peri-urban areas along the coastal area of Benin (West Africa)

The coastal environment represents a special site for human and economic activities. The population growth in this area has led to strong urbanization and, therefore, to the establishment of small-scale vegetable farms to feed the growing urban and peri-urban populations. This is an opportunity for youth employment and reduce poverty as this activity generates reliable incomes. However, in recent years, climatic changes and rapid urbanization have influenced agricultural activities in this area. The aim of this study was to characterize market gardening systems along the coastal area of Benin and understand farmers’ perceptions and adaptation strategies in response to the ongoing environmental changes. Data was collected from 130 farms using individual semi-structured questionnaires. A principal component analysis (PCA), K-Mean multivariate classification and statistical inference were used for data analysis. Three farm groups were identified from the hierarchical bottom-up classification: modern coastal farms (MCF, 59.24%), small-scale intra-urban farms (SIF, 35.38%) and traditional co-managed lowland farms (TCF, 5.38%). The perceived environmental changes were mainly temperature increases, strong winds and migration to another farmland. The criteria differentiating the groups were strong winds and variation in the start date of the rains (p < 0.05). According to current strategies farmers in groups 1 and 2 preferred crop diversification, those in group 3 moved their farms. Future strategies range from the early sale of crops to the use of modern watering equipment to the cessation of farming. Thus, sustainable farm management requires the involvement of decentralized structures and local stakeholders to maintain the livelihoods of local populations.

3-year invasive disease-free survival with chemotherapy de-escalation using an 18F-FDG-PET-based, pathological complete response-adapted strategy in HER2-positive early breast cancer (PHERGain): a randomised, open-label, phase 2 trial

PHERGain was designed to assess the feasibility, safety, and efficacy of a chemotherapy-free treatment based on a dual human epidermal growth factor receptor 2 (HER2) blockade with trastuzumab and pertuzumab in patients with HER2-positive early breast cancer (EBC). It used an 18fluorine-fluorodeoxyglucose-PET-based, pathological complete response (pCR)-adapted strategy. PHERGain was a randomised, open-label, phase 2 trial that took place in 45 hospitals in seven European countries. It randomly allocated patients in a 1:4 ratio with centrally confirmed, HER2-positive, stage I-IIIA invasive, operable breast cancer with at least one PET-evaluable lesion to either group A, where patients received docetaxel (75 mg/m2, intravenous), carboplatin (area under the curve 6 mg/mL per min, intravenous), trastuzumab (600 mg fixed dose, subcutaneous), and pertuzumab (840 mg loading dose followed by 420 mg maintenance doses, intravenous; TCHP), or group B, where patients received trastuzumab and pertuzumab with or without endocrine therapy, every 3 weeks. Random allocation was stratified by hormone receptor status. Centrally reviewed PET was conducted at baseline and after two treatment cycles. Patients in group B were treated according to on-treatment PET results. Patients in group B who were PET-responders continued with trastuzumab and pertuzumab with or without endocrine therapy for six cycles, while PET-non-responders were switched to receive six cycles of TCHP. After surgery, patients in group B who were PET-responders who did not achieve a pCR received six cycles of TCHP, and all patients completed up to 18 cycles of trastuzumab and pertuzumab. The primary endpoints were pCR in patients who were group B PET-responders after two treatment cycles (the results for which have been reported previously) and 3-year invasive disease-free survival (iDFS) in patients in group B. The study is registered with ClinicalTrials.gov (NCT03161353) and is ongoing. Between June 26, 2017, and April 24, 2019, a total of 356 patients were randomly allocated (71 patients in group A and 285 patients in group B), and 63 (89%) and 267 (94%) patients proceeded to surgery in groups A and B, respectively. At this second analysis (data cutoff: Nov 4, 2022), the median duration of follow-up was 43·3 months (range 0·0-63·0). In group B, the 3-year iDFS rate was 94·8% (95% CI 91·4-97·1; p=0·001), meeting the primary endpoint. No new safety signals were identified. Treatment-related adverse events and serious adverse events (SAEs) were numerically higher in patients allocated to group A than to group B (grade ≥3 62% vs 33%; SAEs 28% vs 14%). Group B PET-responders with pCR presented the lowest incidence of treatment-related grade 3 or higher adverse events (1%) without any SAEs. Among HER2-positive EBC patients, a PET-based, pCR-adapted strategy was associated with an excellent 3-year iDFS. This strategy identified about a third of patients who had HER2-positive EBC who could safely omit chemotherapy. F Hoffmann-La Roche.

Warming affects leaf light use efficiency and functional traits in alpine plants: evidence from a 4-year in-situ field experiment.

Light use efficiency (LUE) is a crucial determinant of plant productivity, while leaf functional traits directly affect ecosystem functions. However, it remains unclear how climate warming affects LUE and leaf functional traits of dominant species in alpine meadows. We conducted a 4-year in-situ field warming experiment to investigate the eco-physiological characteristics for a dominant species (Elymus nutans) and a common species (Potentilla anserina) on the Tibetan Plateau. The leaf traits, photosynthesis and fluorescence characteristics were measured, along with the soil physical-chemical properties associated with the two species. Experimental warming increased the leaf LUE, maximum photochemical efficiency, non-photochemical quenching, relative water content and specific leaf area for both species. However, there was a decrease in leaf and soil element content. Different species exhibit varying adaptability to warming. Increasing temperature significantly increased the photosynthetic rate, stomatal conductance, transpiration rate, total water content, and specific leaf volume of E. nutans; however, all these traits exhibited an opposite trend in P. anserina. Warming has a direct negative impact on leaf LUE and an indirectly enhances LUE through its effects on leaf traits. The impact of warming on plant photosynthetic capacity is primarily mediated by soil nutrients and leaf traits. These results indicate that the two different species employ distinct adaptive strategies in response to climate change, which are related to their species-specific variations. Such changes can confer an adaptive advantage for plant to cope with environmental change and potentially lead to alterations to ecosystem structure and functioning.

Differences in the Behavioral Parameters of Young Zebu and Composite Bulls Kept on Non-Forested or in Integrated Crop-Livestock-Forestry Systems.

The behavior of ruminants can influence their productive efficiency. The aim of this study was to evaluate the behavior of young zebu and composite bulls kept in pasture production systems, either in a crop-livestock-forest integration or without afforestation. The work was carried out in São Carlos, Brazil (21°57'42″ S, 47°50'28″ W), in a high-altitude tropical climate, from March to July, 2022. Forty young bulls were evaluated, being 20 Nelore (Bos indicus) (342.5 ± 36.6 kg BW; 16.9 ± 1.8 months) and 20 Canchim (5/8 Bos taurus × 3/8 Bos indicus) (338.4 ± 39.8 kg BW; 19.1 ± 1.9 months), equally distributed in full-sun (FS) and integrated crop-livestock-forestry (ICLF) production systems. Behavior was monitored uninterruptedly by an acoustic sensor and accelerometer attached to a collar, and complemented by direct visual assessment, in two one-day campaigns per month. Serum cortisol concentration was assessed monthly. Statistical analyses were conducted using a general linear model at a 5% significance level (SAS, version 9.4). The ICLF system had a milder microclimate and favored thermal comfort. Natural shading influenced grazing, resting, and rumination time. The Canchim bulls were more active when moving and grazing (p < 0.05), even at the hottest times of the day. In turn, the Nelore bulls spent more time resting at all times (p < 0.001), which was shown to be an adaptive strategy in response to environmental stimuli. The Canchim bulls had a longer rumination time than the Nelore bulls (p < 0.001), due to their longer grazing time. The frequency of water and mineral mixture intake did not differ between genotypes, regardless of the production system (p > 0.05). There was no difference in the serum cortisol concentrations of the Nelore and Canchim bulls kept in FS or ICLF (p = 0.082). Thus, young bulls of the different genotypes showed different behaviors, regardless of whether they were kept on pasture without afforestation or in an integrated crop-livestock-forestry system.

The role of maintenance therapy following autologous stem cell transplantation in newly diagnosed multiple myeloma: Considerations on behalf of the Chronic Malignancies Working Party of the EBMT.

Recent treatment advancements in multiple myeloma have led to significant improvements in patient outcomes. Maintenance therapy following autologous haematopoietic stem cell transplantation (AHCT) is now standard of care and has been demonstrated to prolong and deepen treatment responses. Currently, lenalidomide remains the single agent that has been approved for maintenance post-AHCT in Europe and the USA which, if tolerated, is continued until disease progression. The treatment landscape is rapidly expanding however, and the optimal personalised maintenance approach for a patient is becoming more complex. Treatment outcomes for patients with high-risk disease remain poor and choice of maintenance in this population also remains unclear. This review article evaluates up-to-date literature regarding established maintenance approaches. It further analyses ongoing studies exploring maintenance regimens using combination and novel agents, approaches to maintenance in patients with cytogenetic high-risk disease and minimal residual disease response-adapted strategies that reflect the current evolving treatment paradigm.

Adaptation Strategies in Response to the Effect of Climate Change on Tomato Production

Climate change is one of the largest challenge of this century. Globally, climate change causes drops in yieldfor their most valuable crops, particularly in developing countries. Afghanistan is one of the world's most vulnerablecountries to the negative consequences of climate change. Tomato cultivation is a means of livelihood for most farmersin Afghanistan. The aim of this study was to assess the adaptation strategies on tomato production in response to theimpact of climate change in Ghazni province. The study findings indicate a rise in both maximum and minimumtemperatures, combined with a decline in annual precipitation over the ten years (2008-2017) period in an unreliableseasonal distribution. The study found that the occurrence of pests and diseases had a substantial impact on tomatoproduction due to climate change. Present study highlights the role of climate variables in the production of tomatoes(temperature and precipitation) while controlling other confounding factors. Selection of crop variety according toclimate change and planting time are the two adaptation methods to cope up with the drastic change in the climate toretain the productivity to some extent

An Econometric Analysis to Explore the Temporal Variability of the Factors Affecting Crash Severity Due to COVID-19

This study utilizes multilevel ordinal logistic regression (M-OLR), an approach that accounts for spatial heterogeneity, to assess the dynamics of crash severity in Virginia, USA, over the years 2018 to 2023. This period was notably influenced by the COVID-19 pandemic and its associated stay-at-home orders, which significantly altered traffic behaviors and crash severity patterns. This study aims to evaluate the pandemic’s impact on crash severity and examine the consequent changes in driver behaviors. Despite a reduction in total crashes, a worrying increase in the proportion of severe injuries is observed, suggesting that less congested roads during the pandemic led to riskier driving behaviors, notably increased speed violations. This research also highlights heightened risks for vulnerable road users such as pedestrians, cyclists, and motorcyclists, with changes in transportation habits during the pandemic leading to more severe crashes involving these groups. Additionally, this study emphasizes the consistent influence of environmental and roadway features, like weather conditions and traffic signals, in determining crash outcomes. These findings offer vital insights for road safety policymakers and urban planners, indicating the necessity of adaptive road safety strategies in response to changing societal norms and behaviors. The research underscores the critical role of individual behaviors and mental states in traffic safety management and advocates for holistic approaches to ensure road safety in a rapidly evolving post-pandemic landscape.

A Comprehensive Review on the Impact of Climate Change on Fruit Yield and Quality in Modern Horticultural Practices

This review provides an exhaustive analysis of the impact of climate change on fruit yield and quality, with a specific focus on India's horticultural sector. It synthesizes current research findings, identifies gaps, and suggests future directions to understand and mitigate the effects of climate change on key fruit crops. Climate change, characterized by rising temperatures, erratic rainfall, and extreme weather events, poses significant challenges to fruit production. These challenges under three main sections: the direct and indirect effects of climate change on fruit yield, the influence of climate change on fruit quality, and the adaptations in modern horticultural practices. The direct effects include alterations in flowering and fruiting cycles and changes in pollination dynamics. Indirect effects comprise changes in soil quality and nutrient availability, along with water availability and irrigation challenges. These factors collectively lead to variations in fruit yield across different regions and crops. The review also discusses the impact of climate change on the nutritional content of fruits, such as changes in sugar, acid, vitamin levels, and secondary metabolites that affect flavour and health benefits. Physical and aesthetic changes, including modifications in size, color, texture, and shelf life, are also examined, highlighting their implications for marketability and consumer preference. Adaptation strategies in response to these challenges are crucial. Delves into breeding and genetic modification efforts aimed at developing climate-resilient fruit varieties and discusses the role of biotechnology in these adaptations. It also covers changes in agronomic practices, such as adjustments in planting dates and crop rotation, alongside water management and conservation techniques. The adoption of technological innovations like precision agriculture, monitoring systems, and controlled environment agriculture (CEA) is evaluated for their potential to enhance resilience in fruit production.

Conventional and current approaches of urban mapping and geodetic base formulation for establishing demographic processes database: Tashkent, Uzbekistan

This study explores the integration of historical and modern urban mapping data, an expanded geodetic base, and demographic processes to provide a comprehensive understanding of the dynamic relationships within urban landscapes. Analyzing data spanning from 1950 to 2040, we observe a consistent urban expansion, evolving population density, and shifting land use patterns. The inclusion of ten control points enhances the geodetic base, ensuring precise spatial referencing for urban analyses. Spatially referenced demographic processes data reveal correlations between urban characteristics and population dynamics, guiding targeted interventions for sustainable development. Findings underscore the significance of synergizing conventional and current approaches in urban planning, emphasizing the need for adaptive strategies in response to evolving urban landscapes. Key limitations include potential data quality issues in historical mapping, necessitating ongoing efforts for accuracy enhancement. Future research should focus on refining historical data accuracy and exploring specific urban impacts on demographic dynamics.

The potential of industrial green stormwater infrastructure to provide long-term supplementary flood mitigation for low-lying coastal cities under climate change

Coastal city flooding is projected to worsen in low-lying cities with climate change. Planners are concerned about the inadequacy of their current flood mitigation strategies, and the expense and risk of investing in expensive grey infrastructures, such as levees, under climate uncertainty. Implementing green stormwater infrastructure (GSI) on large privately-owned industrial land may be an attractive alternative; however, little is known about its potential for providing supplementary flood mitigation with climate change. Using Christchurch, New Zealand, as a case study, we applied hydrological modelling and spatial analysis to assess its potential to keep the impact of the increased rainfall intensities within the current flood protection capacity. Increasing groundwater levels due to rising sea levels were also considered to determine land capability for in-ground retention of stormwater. Findings demonstrate significant capability in four out of six catchments to reduce the impact of climate change–induced increased runoff volume to within the current flood protection level in the medium term (2030–2050). Two of the catchments also reduced runoff to this level in the long term (2080–2100), and under much larger storm events than the design storm, though not under all climate scenarios. Long-term flood mitigation capability can be provided where industrial land occupies a large proportion of a catchment’s area, is able to capture runoff from upstream, and where the high water table is deeper than 2 m. Industrial GSI has the potential to provide supplementary surface runoff containment through an adaptive flood mitigation planning strategy in response to unfolding climate change conditions.

Zanubrutinib and Venetoclax As Initial Therapy for CLL/SLL with Obinutuzumab Triplet Consolidation in Patients with Minimal Residual Disease Positivity (BruVenG)

Background: Bruton's tyrosine kinase inhibitors (BTKi), anti-CD20 antibodies, and B cell lymphoma 2 inhibitors (BCL-2i) are essential therapeutic drug classes in the treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Clinical synergy of BTKi and BCL-2i combinations have been observed, which allow for an oral regimen, that can be safely administered in a clinic setting for most patients (Tam et al., 2022; Wierda et al., 2021). Still, it remains uncertain if anti-CD20 antibodies meaningfully add to the effectiveness of oral combination therapy. Recent reports of triplet regimens demonstrate modest improvement in minimal residual disease (MRD) negativity with similar response rates when compared to oral doublets (Davids et al., 2021; Soumerai et al., 2021; Wierda et al., 2021). Additionally, anti-CD20 antibody use causes significant B cell depletion resulting in prolonged immune suppression. Recent reports suggest BTKi use may in fact impair clinical activity of anti-CD20 antibodies, which can be mitigated by using selective BTKi and incorporating anti-CD20 later in the treatment course when lower disease burden is present (Da Roit et al., 2015; Flinsenberg et al., 2020; Pavlasova et al., 2016; Rawstron et al., 2018). Therefore, anti-CD20 therapy may not be required for all patients and could be optimized within a response-adapted strategy. This trial has been developed to assess efficacy and safety of a response adapted consolidative treatment approach utilizing obinutuzumab triplet consolidation in CLL/SLL patients who remain MRD positive after an oral doublet fixed duration treatment with zanubrutinib and venetoclax. This approach looks to maximize MRD negative remissions, spare toxicity by limiting anti-CD20 exposure, and provide a finite therapy. This study will utilize once daily zanubrutinib for which there is limited data in regard to safety and efficacy particularly in combination with venetoclax. Study Design and Endpoints: This is a single center, open label, phase II, investigator initiated clinical trial enrolling 50 subjects evaluating the efficacy and safety of zanubrutinib and venetoclax with obinutuzumab triplet consolidation in subjects who remain MRD positive (BruVenG). Eligible patients must have treatment naïve CLL/SLL and treatment indications per the International Workshop on CLL 2018 guidelines. Subjects with Richter's transformation are excluded. Treatment will consist of lead-in, combination, and consolidation phases. All subjects will be treated with a 3-cycle lead-in of 320mg oral, once daily zanubrutinib monotherapy. Venetoclax will be incorporated at cycle 4, per the standard prescriber insert ramp-up schedule. A final dose of 400mg oral, once daily venetoclax, in combination with 320mg oral, once daily zanubrutinib will be used in all subsequent cycles after ramp-up. At cycle 16, MRD will be assessed in the peripheral blood (PB) and bone marrow (BM) via clonoSEQ (Adaptive Biotechnologies). Subjects who are MRD negative (&amp;lt;1x10 -4 ) in both compartments will stop therapy. Subjects who are MRD positive in PB or BM will continue zanubrutinib and venetoclax for an additional 6 cycles. Obinutuzumab will be added to the oral doublet starting at cycle 17. Standard intravenous obinutuzumab lead-in will occur during cycle 17, followed by standard monthly intravenous dosing of 1000mg through cycle 22. Depending on MRD status, subjects will be treated for 16 or 22 cycles. All subjects who receive consolidation will stop treatment at cycle 23 regardless of end of treatment MRD status. The primary endpoint is cycle 16 PB and BM MRD negativity rates. A co-primary endpoint will be cycle 23 PB and BM MRD negativity rates in subjects who were MRD positive at C16 and who went on to receive at least 1 dose of obinutuzumab. Key secondary endpoints will include cycle 16 overall response rate, 36-month progression free survival, 36-month overall survival, 36-month time to next treatment, 24- and 36-month PB MRD negativity rates, tumor lysis risk reduction rates, and safety. Exploratory endpoints will assess the positive predicative value of the ∆400 biomarker (Soumerai et al., 2021) on MRD negativity at cycle 16. This biomarker will be assessed between cycle 4 and 6. The MRD negative rates at cycle 16 and cycle 23 will be estimated with a 90% confidence interval using the Clopper-Pearson method based on exact binomial distribution.

Impact Analysis of Climate Change on Marine Fisheries Productivity in Indonesian Waters in 2023: A Review of Resource Availability and Adaptation Strategies

This research aims to assess the impact of climate change on the productivity of marine fisheries in Indonesian waters during the year 2023. The study focuses on evaluating the availability of marine resources and exploring adaptation strategies in response to changing environmental conditions. Through a comprehensive analysis, the research seeks to provide insights into the challenges faced by the fisheries sector and propose sustainable measures to ensure the resilience of Indonesia's marine ecosystems.

Strategies employed by Sappi Forests for improved seed production of temperate and sub-tropical pine and eucalypt species, and their hybrids, for long-term sustainability in a changing environment

The annual demand and supply of genetically improved planting stock suitable for sites across varying landscapes, with changing climatic conditions and increasing pest and disease threats are becoming more complex. The agility for effective responses to long-term sustainability of commercial plantations, aimed at different markets, requires a significant investment in genetic resource acquisitions, tree breeding, land management, gene conservation and plant production systems. Tree breeding is one of our most important adaptation strategies in response to climate change and related challenges. These include pests and diseases, drought, frost, and delivery of fit-for-purpose fibre. To supply an annual demand of over sixty million plants, consisting of both pure species seedlings and hybrid cuttings, Sappi requires a well-established pipeline. In addition, this pipeline allows for the sale of between 30 and 40 million viable seeds to both the domestic and international markets. Early acquisition of pine and eucalypt genetic resources suitable for sub-tropical to warm temperate, cool temperate and cold areas has allowed the development of pure species base populations containing genotypes improved for the traits of interest. Through recurrent selection, these populations have been advanced. Key traits include growth, pest and disease tolerance, and wood properties. Various strategies have been adopted to reduce breeding cycles, convert from pure species seedlings to hybrid clonal varieties to sustain productivity. Production of commercial quantities of seed is a key step in translating breeding and development into realised operational gains. A range of orchard types such as breeding seedling seed orchards (BSO), seedling seed orchards (SSO) and clonal seed orchards (CSO) have been developed to produce not only open pollinated seed but also to allow production of control pollinated hybrid seed. Each orchard type and combination of elite genotypes delivers a specific seed product with varying levels of improvement. In addition, associated technologies to produce control pollinated seed have been developed for the advancement of both clonal eucalypt and pine family cutting programmes.

How can Changes in the Human‐Flood Distance Mitigate Flood Fatalities and Displacements?

AbstractComprehending the correlation between alterations in human‐flood distance and flood fatalities (as well as displacements) is pivotal for formulating effective human adaptive strategies in response to floods. However, this relationship remains inadequately explored in existing global analyses. To address this gap, we examine 910 flood events occurring from 2000 to 2018, resulting in significant numbers of fatalities and displacements. We find that in 53% of countries, humans tend to distance from floods, particularly in the Middle East. Such distancing greatly mitigates flood fatalities and displacements. Simultaneously, in areas with increased flood protection level (FPL), humans are less likely to move away from floods. Furthermore, FPL and human‐flood distance have decreased in regions affected by ice jam‐ and hurricane‐induced floods from 2000 to 2018. Notably, regions with human‐flood distance slightly below the average for a given flood type experience more severe flood fatalities.

Farm households’ adaptive strategies in response to climate change in lowlands of southern Ethiopia

PurposeThis study aims to investigate the adaptation strategies they practice and the factors that influence their use of adaptation strategies.Design/methodology/approachThe mixed-method sequential explanatory design was used to triangulate the data collected. Multistage sampling was used to select 400 sampled households for household surveys. Eight focus groups, each with eight to ten participants, and 24 key informants, were specifically chosen based on their farming experiences. Chi-square tests, one-way ANOVA and a binary logit model were used to analyze the data.FindingsThe majority of farmers used simple and low-cost adaptation strategies like changing planting dates, selling livestock and off-farm and nonfarm work. A minority of farmers used advanced adaptation strategies like crop diversification and water harvesting for irrigation. The result further revealed that: the age of the household head, educational status of household heads, farm size, livestock ownership, farming experiences, household income, access to credit and access to climate information significantly influenced the adoption of the adaptation strategies. Public policy should provide water harvesting and irrigation technology, climate-related information and the provision of microcredit facilities to enhance the farmers’ resilience to climate change risks.Originality/valueAlthough several studies on climate change adaptation strategies are available, this paper is one of the few studies focusing on a particular agro-ecological zone, an essential precursor to dealing with current and projected climate change in the area. It provides helpful insights for developing successful adaptation policies that improve adaptive capacity and agricultural sustainability in southern Ethiopia’s lowlands.

Study of Tiu Kulit Dam Reservoir Operational Pattern Simulation in Sumbawa Island

Tiu Kulit Reservoir plays a pivotal role in managing water resources in West Nusa Tenggara, Indonesia, serving as a vital source for raw water, irrigation, and livestock consumption in the neighboring regions. This study aims to assess the operational dynamics of Tiu Kulit Reservoir across varying hydrological conditions, namely dry, normal, and wet years. The analysis is based on inflow rates and equilibrium water surface elevations. To achieve the objectives, an investigation of the reservoir's operation pattern was conducted. Inflow rates and equilibrium water surface elevations were scrutinized to discern operational behaviors under different hydrological scenarios. The findings indicate distinct operational strategies for Tiu Kulit Reservoir. During dry years, the outflow rate is restricted to 1.20 m3/s at a water surface elevation of +53.07 m. Conversely, the reservoir's operation in normal and wet years allows for a maximum outflow rate aimed at satisfying water demand, set at +57.00 m. In instances of excessive rainfall, the study highlights the potential for overflow beyond the spillway threshold. The study underscores the significance of these results for effective water management and resource allocation in the region. Understanding the reservoir's behavior under various conditions enables informed decision-making and sustainable utilization of water resources. To build upon this study, it is recommended to implement continuous monitoring systems for both inflow and outflow rates. Furthermore, the installation of rainfall monitoring stations within the catchment area would enhance data accuracy. Regular evaluations of the reservoir's operational patterns are also advised, allowing for adaptive strategies in response to evolving climate conditions. Moreover, future research endeavors should focus on augmenting water supply to meet the demands of a growing population and livestock, while optimizing agricultural practices to boost productivity.

Adaptation strategies of the Icelandic horse with induced forelimb lameness at walk, trot and tölt.

Lameness assessment in the gaited Icelandic horse is complex. We aimed to describe their kinematic and temporal adaptation strategies in response to forelimb lameness at walk, trot and tölt. In vivo experiment. Ten clinically non-lame Icelandic horses were measured before and after reversible forelimb lameness induction. Upper body and limb kinematics were measured using 11 inertial measurement units mounted on the poll, withers, pelvis (tubera sacrale) and all four limbs and hoofs (Equimoves®, 500 Hz). Horses were measured on a straight line at walk and trot in-hand and at walk, trot and tölt while ridden. Linear mixed models were used to compare baseline and lame conditions (random factor = 'horse'), and results are presented as the difference in estimated marginal means or percentage of change. Lameness induction significantly (p < 0.05) increased head vertical movement asymmetry at walk (HDmin/HDmaxHAND: 18.8/5.7 mm, HDmin/HDmaxRIDDEN: 9.8/0.3 mm) and trot (HDmin/HDmaxHAND: 18.1/7.8 mm, HDmin/HDmaxRIDDEN: 24.0/9.3 mm). At the tölt, however, HDmin did not change significantly (1.1 mm), but HDmax increased by 11.2 mm (p < 0.05). Furthermore, pelvis vertical movement asymmetry (PDmax) increased by 4.9 mm, sound side dissociation decreased (-8.3%), and sound diagonal dissociation increased (6.5%). Other temporal stride variables were also affected, such as increased stance duration of both forelimbs at walk, tölt and in-hand trot. Only one degree of lameness (mild) was induced with an acute lameness model. Classical forelimb lameness metrics, such as vertical head and withers movement asymmetry, were less valuable at tölt compared to walk and trot, except for HDmax. Therefore, it is advised to primarily use the walk and trot to detect and quantify forelimb lameness in the Icelandic horse.

[Comparison of different laryngeal preservation strategies based on chemoradiotherapy in locally advanced hypopharyngeal carcinoma].

Objective:This study aimed to evaluate the clinical features and treatment outcomes of the value of response-adapted treatment following radiotherapy and induction chemotherapy follwing subsequent comprehensive therapy in patients with resectable locally advanced hypopharyngeal carcinoma. Methods:This cohort study was conducted from September 2010 to September 2020 in our hospital, 231 patients pathologically confirmed stage Ⅲ and ⅣB resectable locally advanced hypopharyngeal carcinoma included. For the IC-directed ART strategy, IC is used to select good candidates to receive radical RT or CCRT, and others undergo surgery. He response-adapted strategy was determined based on the primary tumor response, which was evaluated at a dose of 50 Gy. If the response reached complete response or partial response（more than 80% tumor regression）, patients received radical RT or CCRT; otherwise, they received surgery, if possible, at 4 to 6 weeks after RT. The end points of the study were OS（overall survival）, progression free survival（PFS）, locoregional recurrence-free survival（LRRFS） and LDFS. Results:In IC-directed group, 75.0%（57/76） patients reached PR after 2 cycles of induction chemotherapy. While in RT-directed group, 70.3%（109/155） patients reached large PR at dose of 50 Gy. The median interquartile range follow-up period of the whole cohort was 63.8 months. The 5-year OS, PFS, LRRFS and SFL of the whole cohort were 47.9%、39.6%、44.3% and 36.2%, respectively. In evaluations based on the different treatment strategies, the 5-year OS and SFL were 51.3% versus 37.0%（HR 0.67; 95%CI 0.43-1.05; P=0.07） and 27.8% versus 39.8%（HR 0.68; 95%CI 0.46-0.99; P=0.04） between IC-directed and RT-directed groups. In additional, surgery complications did not significantly differ between these two groups. Conclusion:In this cohort study, the response-adapted strategy based on an early RT response facilitated better treatment tailoring, and higher laryngeal preservation compared with IC-directed strategies. This approach could provide a feasible laryngeal preservation strategy in patients with resectable locally advanced hypopharyngeal carcinoma.

Two common, often coexisting grassland plant species differ in their evolutionary potential in response to experimental drought.

For terrestrial plant communities, the increase in frequency and intensity of drought events is considered as one of the most severe consequences of climate change. While single-species studies demonstrate that drought can lead to relatively rapid adaptive genetic changes, the evolutionary potential and constraints to selection need to be assessed in comparative approaches to draw more general conclusions. In a greenhouse experiment, we compare the phenotypic response and evolutionary potential of two co-occurring grassland plant species, Bromus erectus and Trifolium pratense, in two environments differing in water availability. We quantified variation in functional traits and reproductive fitness in response to drought and compared multivariate genetic variance-covariance matrices and predicted evolutionary responses between species. Species showed different drought adaptation strategies, reflected in both their species-specific phenotypic plasticity and predicted responses to selection indicating contrasting evolutionary potential under drought. In T. pratense we found evidence for stronger genetic constraints under drought compared to more favourable conditions, and for some traits plastic and predicted evolutionary responses to drought had opposing directions, likely limiting the potential for adaptive change. Our study contributes to a more detailed understanding of the evolutionary potential of species with different adaptive strategies in response to climate change and may help to inform future scenarios for semi-natural grassland ecosystems.

Is the multi-species variation in leaf anatomical traits along the environmental gradient modulated by herbaceous functional groups?

Grasses are widely distributed in various habitats with significantly different characteristics than non-grass species. However, an understanding of the multi-species differences in leaf anatomical traits variation and adaptive strategies between grass and non-grass species is limited. We measured leaf anatomical traits of 242 species from 10 sampling sites along an environmental gradient on the Loess Plateau (from east to west, environmental temperature, precipitation, and soil nutrients decreased, but radiation increased). Nine leaf anatomical traits were measured, and these traits related to the leaf physiological functions of photosynthesis (mesophyll thickness (MT), palisade tissue thickness (PT), spongy tissue thickness (ST)), defense (epidermal thickness (ET) and leaf thickness (LT)), and transport (xylem conduit diameter (CD) and major vein diameter (MVD)). Subsequently, we calculated the trait ratios, which reflect the proportion of investment in trait construction (epiderm-leaf thickness ratio (ET/LT) and mesophyll-leaf thickness ratio (MT/LT)). The results of linear regression analysis showed that non-grasses living under harsh environmental conditions have thicker leaf tissues responsible for photosynthesis and defense compared to grasses from the same environment. However, grasses and non-grasses living under stressful environmental conditions have higher MT/LT and lower ET/LT compared to species living in environments with a more proper resource supply, which indicated that both preferred to invest less in defense-related traits (e.g., epidermal thickness) while cost more in photosynthesis-related traits (e.g., mesophyll thickness) under the limited resource conditions. These findings highlight that grass and non-grass species have different trait characteristics and adaptive strategies in response to environmental changes. More importantly, a new inspiration is provided for exploring the plants’ general investment rule from the perspective of leaf anatomical trait-ratio values.